15(S)-HETE
| Catalog Number | BL-M000698 |
| CAS Number | 54845-95-3 |
| Description | 15(S)-HETE (HETE) is a metabolite of arachidonic acid via the 15-lipoxygenase pathway. In mammals, 15(S)-HETE is synthesized in the respiratory epithelium, leukocytes, and reticulocytes. 15(S)-HETE suppresses the incorporation of thymidine and biosynthesis of prostaglandin E2 in tumor cell cultures. Treatment of colon cancer cells with 15(S)-HETE inhibited cell proliferation and induced apoptosis, which was preceded by an increase in TGF-beta-inducible early gene (TIEG) and a decrease in Bcl-2. |
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| IUPAC Name | (5Z,8Z,11Z,13E,15S)-15-hydroxyicosa-5,8,11,13-tetraenoic acid |
| Synonyms | Icomucret; 15(S)-hydroxyeicosatetraenoic acid; 15(S)-Hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoic acid |
| Molecular Weight | 320.47 |
| Molecular Formula | C20H32O3 |
| Boiling Point | 487.7±45.0 °C at 760 mmHg |
| Purity | >99% |
| Density | 0.984±0.06 g/cm3 |
| Appearance | Ethanol |
| Shelf Life | 1 Year |
| Storage | Store at -20°C |
| Percent Composition | C 74.96% H 10.06% O 14.98% |
| Canonical SMILES | CCCCCC(C=CC=CCC=CCC=CCCCC(=O)O)O |
| InChI | InChI=1S/C20H32O3/c1-2-3-13-16-19(21)17-14-11-9-7-5-4-6-8-10-12-15-18-20(22)23/h4-5,8-11,14,17,19,21H,2-3,6-7,12-13,15-16,18H2,1H3,(H,22,23)/b5-4-,10-8-,11-9-,17-14+/t19-/m0/s1 |
| InChI Key | JSFATNQSLKRBCI-VAEKSGALSA-N |
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