Materials for liposomes

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BOC Sciences provides our customers with high-quality materials for liposomes. All materials are prepared under sterile conditions

Introduction

Liposomes are microvesicles with an aqueous chamber, surrounded by amphiphilic molecular bilayers. When liposomes enter the body, the reticuloendothelial system mainly engulfed them, thereby activating the autoimmune function in the body, and changing the absorption and distribution of the encapsulated drugs in the body. It allows the drug to accumulate in the heart, liver, lung and bone marrow and other tissues and organs, thus reducing the therapeutic dose of the drug and reducing the toxicity of the drug, and achieving the purpose of targeted drug delivery.

Materials for liposomes

Composition of Liposomes

  • Neutral phospholipids

Including Phosphatidylcholine (PC), phosphatidylethanolamine (PE), sphingomyelin (SM).

  • Negative charged phospholipids (acidic phospholipids)

Including phosphatidic acid (PA), phosphatidylglycerol (PG), phosphatidylinositol (PI), phosphatidylserine (PS).

  • Positive-charged lipids

Including sterylamine (SA), and cholesterol derivatives.

  • Stigmasterol and its glucoside

Including sterol glycosides (SG), and soybean sterol (SS).

  • Cholesterol

Structure of Liposomes

The hydrophilic end of the phospholipid molecule is curved in an arc and combines with the hydrophilic group of the cholesterol molecule to form a "U" shaped structure. The two "U" shaped structures are arranged opposite each other to form a bimolecular structure.

Various substances can be encapsulated in the membrane composed of the aqueous phase and lipid bilayer of liposomes:

  • Fat-soluble drugs
  • Water-soluble drugs
  • Amphoteric compounds

Physicochemical Properties of Liposomes

  • Phase transition temperature (Tc)
  • Membrane permeability
  • Membrane fluidity
  • Liposome chargeability

Our Advantages

  • Manufacturing process in compliance with GMP requirements
  • High-quality lipid raw materials
  • Strict quality inspection and quality control
  • The most competitive price in the entire network
※ Only for research. Not suitable for any diagnostic or therapeutic use.

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