Biotinylated Liposomes

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Biotinylated liposomes have a biotin moiety and are primarily used for conjugation to proteins with (streptavidin) affinity or biotin, such as antibodies. BOC Sciences manufactures biotinylated liposomes that have been widely used in preclinical and laboratory applications, and have demonstrated good efficiency and success in conjugating antibodies especially downstream, assisting customers in advancing the development of immunotherapies.

What are Biotinylated Liposomes?

Biotin Modification

Biotin belongs to the B vitamins, also known as Vitamin H, Vitamin B7 and Coenzyme R. Biotin is a coenzyme for a variety of carboxylases and acts as a CO₂ carrier in carboxylase reactions. In particular, biotin binds strongly and specifically to affinin or streptavidin proteins and can be used in a variety of biological and biochemical applications such as protein purification, cell labeling, and for the preparation of biotinylated molecules. Biotin modification is a versatile tool in the life sciences, enabling selective and specific affixation of biotinylated molecules to affinity or streptavidin, such as for the preparation of immunolipids.

Figure 1. Structural formula of biotin.

Biotin-modified Liposomes

Biotinylated liposomes have a strong affinity for biotin and streptavidin. Anti-biotin proteins and streptavidin anti-biotin proteins have multiple biotin binding sites and the interaction between biotin and these proteins is one of the strongest non-covalent interactions in biology. BOC Sciences' application of biotinylated liposomes is based on this strong and specific binding of biotin-streptavidin.

Figure 2. Biotin-modified Liposomes. (Q, Wu.; et al, 2020)

Applications of Biotinylated Liposomes

Biotinylated liposomes can be used for targeted drug delivery. By first attaching biotin to the surface of the liposome and then attaching a drug or therapeutic agent that is conjugated to an anti-biotin protein or streptavidin anti-biotin protein, the liposome can be targeted to specific cells or tissues that express anti-biotin protein/streptavidin anti-biotin protein receptors.

Biotinylated liposomes may be used for imaging purposes. Imaging agents labeled with amphiphiles or streptavidin can be attached to biotinylated liposomes to visualize specific cell or tissue targets.

Biotinylated liposomes can be used for biosensors and diagnostic analysis. They can serve as a capture surface for affinity or streptavidin-labeled biomolecules, enabling the detection of specific analytes in a sample.

Advantages of BOC Sciences' Biotinylated Liposomes

High Quality: BOC Sciecnes' biotinylated liposomes undergo multiple steps of purification and stringent quality control to ensure that you receive a high purity product.

Customizability: With GMP-grade synthesis capabilities and technical support, BOC Sciecnes offers a range of individually tailored biotinylated liposomes to meet customers' needs for different projects.

Price Advantage: BOC Sciecnes' products are reasonably priced, providing quality products with price advantages within budget.

Professional Technical Support and Perfect After-sales: BOC Sciecnes' professional technical support team can provide customers with professional technical consultation and after-sale technical support.

For more custom services about our biotinylated liposomes, please feel free to contact us.

Reference

Q, Wu.; et al. Studies on Biotinylated Liposomes as Potential Carries for Enhancing Oral Absorption of Curcumin. International Journal of Nanoparticles and Nanotechnology. 2020, 6(1).