Cationic Liposomes

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BOC Sciences provides a series of cationic liposomes for plasmid DNA, antisense, siRNA, etc. delivery.

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What is Cationic liposome?

Cationic liposomes are the core components of nanoparticles, with a common structure of a positively charged head group and one or two hydrophobic tail regions made of hydrocarbon chains or steroid structures.

Synthesis method for cationic lipid

Different endocytic pathways may be related to the composition of cationic liposomes

The lipid composition of liposomes affects the structural properties and transfection efficiency of cationic lipids

Cationic liposomes composed of 3β-[ N-(N',N'-dimethylaminoethane)carbamoyl]cholesterol (DC-Chol) and DOPE are considered to be representative liposomes that effectively deliver genes . For the delivery of plasmid DNA, the most effective molar ratio of DC-Chol to DOPE was found to be 1:2. The transfection efficiency of plasmid DNA decreases as the weight ratio of DC-Chol to plasmid DNA increases, and the highest efficiency is 3:1.

Strategies for cationic liposome-based nucleic acid delivery Figure 1: Strategies for cationic liposome-based nucleic acid delivery (Gayong Shim, 2013).

Advantages of Cationic liposome

Cationic liposomes are used to deliver various nucleic acids, such as plasmid DNA, antisense oligonucleotides, and siRNA. As a nucleic acid delivery system, cationic liposomes have many advantages.


  1. Gayong Shim, Mi-Gyeong Kim, Joo Yeon Park, Yu-Kyoung Oh. Application of cationic liposomes for delivery of nucleic acids. Asian Journal of Pharmaceutical Sciences. 2013; 8(2):72-80.
  2. Yinan Zhao, Defu Zhi and Shubiao Zhang. Cationic Liposomes in Different Structural Levels for Gene Delivery. Non-Viral Gene Therapy. 2011:293-318.
  3. Carola Hofmann, Barbara Kaiser, Susanne Maerkl, Axel Duerkop & Antje J. Baeumner. Cationic liposomes for generic signal amplification strategies in bioassays. Analytical and Bioanalytical Chemistry. 2020; 412:3383-3393.
  4. Jeroen Heuts, etc. Cationic Liposomes: A Flexible Vaccine Delivery System for Physicochemically Diverse Antigenic Peptides. Pharm Res. 2018; 35(11):207.

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