Lipid Nanoparticles (LNPs)

BOC Sciences provides our clients with customized lipid nanometers to meet the different needs using our advanced lipid nanoparticle (LNP) technology, which represents the most widely used RNAi delivery technology to date. The LNP technology allows RNAi drugs/mRNA/small molecule drugs to be encapsulated in tiny particles made of lipids (fat or oil).

Why the Lipid Nanoparticles (LNPs)？

Lipid Nanoparticle (LNPs) delivery systems are attractive due to the ease of manufacturing, reduced immune response, multi-dose capabilities, greater payload, and design flexibility. The LNPs system represents the most advanced non-viral delivery system for the in vivo delivery of small molecules and genetic drugs with clinical potential.

Figure 1: Scheme of an LNP structure.

Advantages of LNPs

• Higher nucleic acid encapsulation efficiency and effective transfection efficiency
• Increased penetration of tissue to provide treatment
• Protected the potent trigger in LNPs
• Low cytotoxicity and immunogenicity

What We Provide?

We provide high-quality liposome nanoparticle formulation services. We can design and configure lipid nanoparticles based on different loads. We have successfully developed many innovative formulations using the LNP transportation technology and optimized manufacturing processes, and we are able to promote research and even commercialization of LNP-based products.

How We Do?

• Liposomal formulation design/preparation/ encapsulation
• Analysis and characterization of liposome products
• Freeze-protectant and delivery

Preparation Methods for LNPs

• Solvent Based Methods
• Microfluidic technologies
• Coacervation techniques
• Microemulsion templates methods
• Based on supercritical fluid methods
• Membrane contactor method
• Phase transition temperature method

Applications

• Drug delivery to treat diseases (e.g. immuno-oncology and rare hereditary and non-communicable diseases)
• Gene editing
• Rapid vaccine development

Reference

1. Yi Zhao and Leaf Huang. Lipid Nanoparticles for Gene Delivery. Adv Genet. 2014; 88: 13–36.