Lipid Microspheres Synthesis Service

Introduction to Our Lipid Microspheres Synthesis Service

In the realm of advanced drug delivery systems, lipid microspheres represent a paradigm shift toward safer, more efficient, and highly targeted therapeutic strategies. As a liposome expert, BOC Sciences, in addition to offering a range of custom synthesis services for liposomes, is also committed to developing a variety of lipid-based drug delivery systems to support preclinical drug development. Here at BOC Sciences, we offer premium lipid microsphere synthesis services. With years of expertise in lipid chemistry and nano-formulation, we design precise, scalable microsphere systems optimized for a wide range of bioactive compounds. Our synthesis solutions are designed to meet the demanding needs of pharmaceutical and biotechnology innovators seeking next-generation drug delivery tools.

How to Get Started with Us?

  • Reach out to us by visiting our website or contacting us via email to initiate a conversation about your lipid microspheres synthesis project.
  • Schedule a consultation with our team to discuss your project's objectives, goals, and specific requirements in detail.
  • Our experts will assess the feasibility of your project and provide initial feedback on the best approach for lipid microspheres synthesis.
  • We will present a comprehensive development plan, including timelines, cost estimates, and key project milestones.
  • Once all parties agree on the terms, we will proceed with the signing of a formal contract, officially commencing the project.

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What are Microspheres in Drug Delivery?

Microspheres function as submicron-to-micron scale spherical particles which enable the encapsulation of therapeutic agents for controlled and targeted delivery. The structure of microspheres in lipid-based formulations relies heavily on biocompatible phospholipids and triglycerides which produce enhanced membrane mimicry alongside superior physiological compatibility. Lipid microspheres demonstrate superior bioavailability and drug solubility while minimizing systemic toxicity compared to polymeric microspheres. Lipid microspheres protect labile molecules from degradation and use natural lipid pathways to deliver drugs which makes them suitable for preclinical studies with hydrophobic drugs as well as peptides, proteins and nucleic acids.

Comprehensive Services for Liposomal Drug Controlled Release System Development

At BOC Sciences, our lipid microsphere synthesis services cover the full spectrum of preclinical formulation development. We customize each project based on the physicochemical characteristics of the payload and the intended delivery route, ensuring consistent performance across in vitro and in vivo models.

High-Purity Lipid Raw Materials for Lipid Microspheres Synthesis

We supply a comprehensive portfolio of high-purity lipid excipients and formulation enhancers, selected based on biocompatibility, regulatory acceptability, and functional performance in microsphere construction:

(1) Natural and Synthetic Phospholipids

(2) Neutral Lipids and Triglycerides

  • Medium- and long-chain triglycerides (MCT, LCT) for sustained release
  • Glyceryl behenate, glyceryl monostearate for depot and injectable formulations

(3) Charged Lipids and Ionizable Lipids

(4) Stabilizers and Surfactants

  • PEG-lipids (DSPE-PEG2000, mPEG-DSPE) for stealth properties
  • Polysorbates, poloxamers, lecithins for enhanced emulsification and stability

Lipid Microsphere Types Offered

BOC Sciences specializes in the fabrication of customizable lipid microsphere types to match distinct physicochemical profiles and therapeutic delivery goals:

  • Solid Lipid Microspheres (SLMs): Constructed using solid lipids at room temperature, these structures provide controlled release and excellent physical stability for hydrophobic APIs.
  • Nanostructured Lipid Carriers (NLCs): A hybrid matrix system of solid and liquid lipids, ideal for improving drug loading and avoiding drug expulsion during storage.
  • Cationic Lipid Microspheres: Designed for complexing with nucleic acids such as siRNA, mRNA, or plasmid DNA for gene therapy applications.
  • PEGylated Lipid Microspheres: Featuring stealth properties for prolonged systemic circulation and enhanced EPR (enhanced permeability and retention) effects in tumor models.
  • Targeted Ligand-Conjugated Microspheres: Surface-functionalized with folate, RGD peptides, or monoclonal antibodies for receptor-mediated uptake in tumor or inflammation models.

Tailored Lipid Microsphere Drug Delivery

BOC Sciences formulates lipid microspheres for a wide range of payload classes, addressing solubility, stability, release kinetics, and biodistribution challenges:

  • Hydrophobic Small Molecules: e.g., paclitaxel, docetaxel, curcumin, dexamethasone – improving solubility and bioavailability through lipid encapsulation.
  • Peptides and Proteins: e.g., insulin, calcitonin, interferons – protected from enzymatic degradation, delivered via sustained-release microspheres.
  • RNA and DNA Therapeutics: siRNA, antisense oligonucleotides, CRISPR components – formulated in ionizable lipid microspheres with endosomal escape capability.
  • Vaccines and Adjuvants: Encapsulation of protein subunits or adjuvants to enhance antigen presentation, facilitate lymphatic targeting, and modulate immune response.
  • Photosensitive or Labile Molecules: Lipid microspheres can shield APIs from oxidative, thermal, or enzymatic degradation for enhanced formulation integrity.

Step-by-Step Process of Lipid Microspheres Synthesis Service

Our synthesis workflow follows a robust, scientifically validated protocol to ensure reproducibility, scalability, and performance across preclinical stages:

1. Project Consultation and Feasibility Analysis

Initial consultations involve a thorough evaluation of the active pharmaceutical ingredient (API) and its compatibility with lipid-based delivery systems. This includes an assessment of the drug's physicochemical properties, solubility, stability profiles, and desired release characteristics. From this analysis, we outline the feasibility of encapsulation and tailor an approach to meet your project's specific goals.

2. Lipid Matrix Selection and Design

Based on the API's characteristics and the intended application, we select an appropriate lipid composition. This may include phospholipids (e.g., phosphatidylcholine), cholesterol, triglycerides, and surfactants. Each lipid component is chosen for its ability to enhance stability, encapsulation efficiency, and compatibility with the drug's delivery requirements, such as sustained release or targeted delivery.

3. Formulation and Process Optimization

In this phase, we experiment with various formulation variables to determine the optimal conditions for lipid microsphere synthesis. This involves adjusting parameters such as lipid-to-drug ratio, temperature, emulsifier type, pH, and processing methods to achieve high drug loading capacity and stable microsphere formation. Multiple formulations are evaluated to maximize encapsulation efficiency and control particle size.

4. Microsphere Fabrication

With the optimal formulation in place, we employ various methods such as high-shear homogenization, sonication, and solvent evaporation to fabricate the lipid microspheres. The goal is to create uniform, spherical particles with controlled size and morphology. The microspheres are formed under carefully controlled conditions to ensure reproducibility and scalability, while maintaining high drug encapsulation efficiency.

5. Analytical Characterization

Once the lipid microspheres are synthesized, they undergo a comprehensive suite of analyses to assess their size, surface charge, drug loading, and morphology. Techniques such as dynamic light scattering (DLS) for particle size distribution, transmission electron microscopy (TEM) or scanning electron microscopy (SEM) for morphology, and high-performance liquid chromatography (HPLC) for encapsulation efficiency are employed. Additionally, in vitro release kinetics are assessed under simulated physiological conditions to confirm the desired drug release profile.

6. Preclinical Batch Manufacturing

Following the optimization and validation of the formulation, we scale up the production of lipid microspheres for preclinical studies. This includes the manufacturing of larger batches that are used for pharmacokinetics, biodistribution, toxicology, and efficacy studies. During this phase, we ensure that the formulation maintains consistency and performance across different scales of production, supporting the transition to more extensive preclinical testing.

Benefits of Our Lipid Microspheres Synthesis Service

Applications of Our Lipid Microspheres Synthesis Service

Lipid microspheres offer a versatile platform for drug delivery, with significant advantages in various therapeutic areas. At BOC Sciences, we specialize in synthesizing lipid microspheres that can be customized for specific drug delivery needs.

Targeted Drug Delivery in Cancer Therapy

Lipid microspheres enable targeted delivery of chemotherapy agents directly to tumor sites, reducing systemic toxicity and improving drug efficacy. By encapsulating drugs, lipid microspheres enhance stability, solubility, and controlled release, while minimizing side effects like nausea and hair loss. They can also be engineered to target specific tumor markers, improving precision and combating multidrug resistance in cancer cells.

Gene Therapy: Efficient Delivery of Nucleic Acids

In gene therapy, lipid microspheres facilitate the safe delivery of DNA, RNA, and other genetic materials. Their biocompatibility and ability to encapsulate both hydrophobic and hydrophilic molecules allow for efficient gene editing applications, such as CRISPR. Lipid microspheres protect genetic material from degradation and enable sustained gene expression, which is essential for treating genetic disorders.

Vaccine Development: Enhancing Immunogenicity

Lipid microspheres improve vaccine formulations by encapsulating antigens and adjuvants, enhancing stability and immune response. Their controlled release properties ensure a stronger, longer-lasting immune response, especially in vaccines targeting complex pathogens. This makes lipid microspheres invaluable in both traditional and mRNA-based vaccine development.

Protein and Peptide Drug Delivery

Lipid microspheres protect proteins and peptides from degradation and improve their bioavailability. By encapsulating biologics, they ensure sustained release, which is particularly useful for peptide therapies like insulin and GLP-1 analogs. This enhances the effectiveness of treatments and improves patient compliance by reducing the frequency of administration.

Brain-Targeted Drug Delivery

Lipid microspheres can overcome the blood-brain barrier (BBB), delivering drugs directly to the brain. By modifying surface properties, lipid microspheres facilitate the transport of therapeutic agents for neurological disorders such as Alzheimer's and Parkinson's. This enables more effective treatments for conditions where traditional drug delivery methods fall short.

Sustained and Controlled Release of Therapeutic Agents

Lipid microspheres enable controlled, sustained release of drugs over time, making them ideal for chronic disease management. Whether for pain management, hormonal therapies, or vaccines, this feature improves patient compliance and ensures continuous therapeutic effects with fewer doses.

FAQs – Insights about Our Lipid Microspheres Synthesis Service

Product

Can you accommodate specific targeting strategies, such as organ- or cell-specific delivery?

Yes. We offer surface modification services including ligand conjugation (e.g., antibodies, folate, peptides) and PEGylation to enable active targeting to specific tissues, such as tumors, liver, or immune cells.

How do you determine the optimal lipid composition for a specific drug?

We perform detailed pre-formulation screening, considering drug solubility, stability, charge interactions, and intended administration route. This allows us to rationally select and optimize lipid types and ratios (e.g., neutral lipids, cationic lipids, anionic lipids).

Can you re-engineer an existing lipid microsphere formulation to improve performance?

Certainly. We often assist clients in reformulating existing lipid microsphere systems to improve encapsulation efficiency, reduce burst release, or enhance targeting—based on thorough characterization and mechanistic understanding.

Do you offer microfluidics-based synthesis for lipid microspheres to ensure narrow size distribution?

Yes. We implement microfluidic mixing platforms to achieve highly uniform lipid microspheres with narrow polydispersity indices (PDI < 0.2). This enables better reproducibility and predictable pharmacokinetics, particularly for small-volume, high-value preclinical candidates.

Partner with BOC Sciences to unlock the full potential of lipid-based delivery systems. Our synthesis services go beyond formulation—we deliver precision, performance, and preclinical confidence. Contact us today to accelerate your drug delivery innovation with custom-engineered lipid microspheres.

Supplementary Knowledges: Lipid Microspheres

What is the difference between microspheres and liposomes?

Microspheres are solid or semi-solid spherical particles typically made from polymers or lipids that encapsulate active agents throughout the matrix or in a core-shell configuration. Liposomes, in contrast, are vesicular structures composed of lipid bilayers surrounding an aqueous core, ideal for encapsulating hydrophilic and hydrophobic drugs separately. Lipid microspheres often refer to lipid-based particulate systems with properties intermediate between these two.

What is sulfur hexafluoride lipid microspheres?

Sulfur hexafluoride lipid microspheres are gas-filled lipid-based microspheres commonly used as ultrasound contrast agents. The sulfur hexafluoride gas core provides strong echogenicity, while the phospholipid shell stabilizes the microsphere in circulation, making them suitable for vascular imaging in diagnostic applications.

Is perflutren lipid microsphere safe?

Perflutren lipid microspheres, commonly used as ultrasound contrast agents, are generally considered safe when administered according to approved guidelines. The lipid microsphere formulation, which contains a perflutren gas core, has been extensively studied for its safety in diagnostic imaging.

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