Custom Liposomes Synthesis Services

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  Intelligent Responsive Liposome

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  Liposome Targeted Modification Services

• Multivesicular Liposomes Synthesis Service

As an excellent drug carrier, liposome has a small particle size, similar to the structure of human biofilm (both hydrophilic and hydrophobic), and at the same time has good biocompatibility, drug encapsulation and release ability. In the field of oncology, liposomes have the advantages of resisting drug resistance and improving drug solubility, which can effectively improve drug targeting and stability, thus improving drug efficacy and reducing systemic toxicity and side effects. With the increasing demand for innovative drug delivery solutions, BOC Sciences provides cutting-edge custom liposomes synthesis Services, offering tailored liposome formulations to meet specific therapeutic and research needs.

BOC Sciences' Custom Liposomes Synthesis Services

At BOC Sciences, we provide custom synthesis services to ensure each kind of liposomal formulation comes with the best performance, stability, and efficiency. The production competence of liposomes at our company is based on decades-long research, industry experience, and the latest technologies. Our team has been committed to one-stop liposomal CDMO services for global customers through the whole industry chain from raw material supply to the commercial-scale production of the final product.

Figure 1: Schematic of the liposome formation process. Panel A shows a schematic of a microfluidic device; Panel B shows a schematic of the ethanol injection procedure.

Microfluidics – Our Liposome Synthesis Technology Platform

One of the significant technological advancements in synthesizing liposomes is represented by microfluidics. By using this technology, BOC Sciences ensures that the size of liposomes, their shape, and encapsulation efficiency could be precisely controlled. Basically, the microfluidic technique is based on the mixing of the lipid phase and the aqueous one across micro-channels. This methodology ensures the generation of highly homogeneous liposomes with controlled size distribution and lamellarity. This approach offers several advantages, including:

• Precise Control of Liposome Size and Morphology: Microfluidics offers precise control over liposome size and shape by improving the mixing of lipids and aqueous phases. This results in uniform liposomes with narrow size distributions, critical for optimizing pharmacokinetics and targeting efficiency.
• Enhanced Encapsulation Efficiency: Microfluidics improves encapsulation efficiency, ensuring more therapeutic agents, especially hydrophobic drugs and large biomolecules, are retained inside the liposomes, enhancing drug delivery performance.
• High Reproducibility and Scalability: Microfluidic systems provide consistent results, minimizing batch-to-batch variability and making it easier to scale from lab to commercial production, ensuring high-quality liposomal formulations for clinical use.
• Reduced Production Time and Costs: Microfluidics simplifies the liposome synthesis process, reducing steps, production time, and reagent usage, ultimately lowering production costs compared to traditional methods.

By integrating microfluidic technology into our liposome synthesis processes, BOC Sciences can produce liposomes with unparalleled precision and efficiency, making it an ideal choice for clients seeking high-quality liposomal formulations.

Lipids Raw Material & Liposomal Products Supply

The selection of the right lipids and materials is critical in designing an effective liposome formulation. BOC Sciences offers a comprehensive range of lipids, surfactants, and other raw materials necessary for liposome production. These materials can be customized to meet the specific needs of each client. We supply various phospholipids, cholesterol derivatives, and other lipidic components.

• Choose for Materials for Liposomes

• Choose for Liposomal Products

In addition, we offer a wide range of high-quality liposome products, covering a wide range of specifications and applications. These liposome products are widely used in drug delivery systems, gene therapy, vaccine development, cell research, and molecular biology.

All liposome products undergo strict quality control and testing to ensure that each batch of products meets industry standards. We also offer customized liposome solutions that can adjust the composition, size and surface finish of liposomes to the specific needs and application scenarios of our customers to achieve the best results.

Tailored Liposome Formulation Service

At BOC Sciences, our Custom Liposomes Synthesis Services are designed to meet the specific needs of our clients, whether in drug delivery, gene therapy, or diagnostic applications. We offer comprehensive liposome formulation services, ranging from liposome design to large-scale production.

• Lipid Nanoparticles (LNPs) Formulation Service
  BOC Sciences excels in Lipid Nanoparticle (LNP) Formulation Services, a cutting-edge approach that enhances the delivery of nucleic acids, such as mRNA and siRNA. LNPs are particularly important in gene therapy and vaccine development. Our services offer:
  • Tailored lipid compositions for LNPs that ensure high encapsulation efficiency and stability.
  • Design optimization for specific drug delivery systems, ensuring controlled release and targeted delivery.
  • Integration with our advanced microfluidic technology to achieve high-quality nanoparticles with consistent size and lamellarity.
• Conventional Liposome Formulations
  Conventional liposomes are lipid bilayer vesicles composed primarily of phospholipids and cholesterol. These vesicles encapsulate an aqueous core that can carry water-soluble therapeutic agents, while the lipid bilayer can encapsulate hydrophobic drugs or molecules. The size and composition of conventional liposomes can be customized to suit specific application needs, making them ideal for a wide range of pharmaceutical, cosmetic, and biotechnological purposes. Among the different types of liposomal formulations, conventional liposomes remain one of the most commonly used due to their simplicity, versatility, and effectiveness. At BOC Sciences, we specialize in providing custom conventional liposome formulation services that can be tailored to meet the specific needs of our clients across diverse therapeutic applications.
• Intelligent Responsive Liposome Synthesis
  Responsive liposomes are designed to change their properties in response to external stimuli, such as pH, temperature, or enzymes. BOC Sciences specializes in the design and synthesis of Intelligent Responsive Liposomes, which are particularly useful for targeted drug delivery systems. These liposomes are engineered to release their encapsulated drugs under specific conditions, ensuring that the active compound is released at the site of action, minimizing side effects and improving therapeutic efficacy.
  • Custom Enzyme-responsive Liposome Service: BOC Sciences offers enzyme-responsive liposomes that release their payloads upon encountering specific enzymes, ideal for targeted drug delivery in disease-specific environments. This service ensures precise control over drug release in response to enzymatic activity.
  • Custom Magnetic Sensitive Liposome Service: Our magnetic-sensitive liposomes are designed to respond to external magnetic fields, enabling targeted drug delivery and enhanced localization at the desired site. This service is particularly useful for applications in cancer therapy and tissue engineering.
  • Custom Photo-responsive Liposome Service: BOC Sciences provides photo-responsive liposomes that release their encapsulated payloads upon exposure to light, offering precise spatial and temporal control over drug delivery. This technology is useful in applications requiring light-triggered therapeutic or diagnostic agents.
  • Custom PH-Responsive Liposome Service: Our pH-responsive liposomes are engineered to release their contents in response to changes in pH, making them ideal for targeted delivery in acidic environments such as tumor tissues or intracellular compartments. This service is tailored for cancer and gene therapy applications.
  • Custom ROS-Responsive Liposome Service: BOC Sciences specializes in liposomes that release their cargo in the presence of reactive oxygen species (ROS), commonly found in oxidative stress conditions. These liposomes offer precise control over drug release in diseases characterized by ROS accumulation, such as cancer.
  • Custom Temperature Sensitive Response Liposome Service: Our temperature-sensitive liposomes release their encapsulated agents upon exposure to specific temperatures, providing controlled release in response to localized heat or hyperthermic conditions. This service is particularly effective for applications in localized cancer therapy.
• Multivesicular Liposomes Synthesis Service
  Liposomes that contain multiple internal vesicles, allowing for the encapsulation of multiple drugs or multiple formulations of the same drug. MVLs can offer enhanced therapeutic efficacy by enabling controlled and sustained drug release.
• Liposome Targeted Modification Services
  BOC Sciences offers liposome targeted modification services, enabling the design and synthesis of liposomes with specific targeting ligands such as antibodies, peptides, or small molecules. This customization enhances the selective delivery of therapeutics to specific cells or tissues, improving the efficacy and reducing off-target effects in applications like cancer therapy and gene delivery.
  • PEGylation Liposome: The addition of polyethylene glycol (PEG) to the liposome surface can improve the stability and circulation time of liposomes, reducing immune system recognition and increasing drug bioavailability.
  • Custom Peptide-Functionalized Liposome Service: Our peptide-functionalized liposomes are tailored to display specific peptides on their surface for targeted delivery to cells with corresponding receptors. This service allows for highly selective targeting, ideal for applications in drug delivery, diagnostics, and vaccine development, where precise cellular targeting is critical.
  • Polymer-Modified Liposomes Synthesis Service: BOC Sciences provides polymer-modified liposomes, incorporating synthetic or natural polymers onto the liposome surface to improve stability, circulation time, and targeting ability. This modification enhances the pharmacokinetics and therapeutic efficacy of liposomes in applications such as sustained drug release and gene therapy.

Scalable Liposome Production

Whether you require small-scale research formulations, preclinical batches, or large-scale commercial production, BOC Sciences has the capacity and expertise to handle all stages of liposome production. Our scalable liposome manufacturing services ensure consistency and reproducibility across different production scales, from laboratory bench-top experiments to industrial-scale commercial batches. You can choose for:

• Laboratory-scale production for early-stage research and development.
• Preclinical-scale production for testing in animal models.
• Commercial-scale production for large-scale manufacturing with quality assurance and regulatory compliance.

Why Choose BOC Sciences' Custom Liposome Synthesis Services?

At BOC Sciences, we are committed to providing high-quality, customized liposome synthesis services that meet the diverse needs of our clients.

• Tailored Solutions: Our team of experts works closely with clients to design custom liposomes that meet specific therapeutic and research needs.
• Cutting-Edge Technology: We utilize advanced techniques, including microfluidics and responsive liposome technology, to ensure optimal drug delivery performance.
• Scalable Production: From lab-scale to commercial-scale production, we have the capacity to handle projects of any size, ensuring smooth transitions from research to clinical and commercial phases.
• Comprehensive Support: Our services go beyond liposome synthesis to include formulation design, optimization, and modification, ensuring complete solutions for our clients.

FAQ of Custom Liposome Synthesis Services

1. Can BOC Sciences design liposomes for specific applications?

Yes, BOC Sciences specializes in designing liposomes tailored for specific therapeutic or diagnostic applications, including drug delivery, gene therapy, and imaging.

2. What is the lead time for custom liposome synthesis?

The lead time for custom liposome synthesis depends on the complexity and scale of the project. Typically, small-scale formulations can be delivered in a few weeks, while larger-scale production may require more time for optimization and regulatory compliance.

3. Do you provide post-synthesis support?

Yes, we provide comprehensive post-synthesis support, including liposome characterization, optimization, and scaling up for production. You have access to a comprehensive one-stop shop for liposomal CDMO services at BOC Sciences.

4. How does BOC Sciences ensure the quality of liposomes?

We utilize advanced technologies like microfluidics for precise control over liposome size and lamellarity, ensuring consistency and reproducibility across all production stages. We offer cGMP services and will maintain strict quality control throughout our services.