Bile Acids

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Bile acids are carboxylic acids that are present in bile, which is the primary solid component produced by the liver. They play crucial roles in various physiological processes. BOC Sciences provides a broad range of bile acids for use in scientific research, covering biomedical, medical device, food, environmental, and related fields. Every product undergoes rigorous quality control checks to ensure high purity and quality, fulfilling customers' demands for top-quality bile acids.

What is Bile Acids

Bile acids are an important component of the digestive system, produced by the liver, stored in the gallbladder, and secreted into the small intestine. Bile acids are classified as secondary and primary bile acids, which are essential for facilitating the digestion, absorption and metabolism of dietary fats, vitamins and other nutrients.

  • Structure of Bile Acids

Bile acids are steroid molecules that are synthesized in the liver from cholesterol. Primary bile acids include bile acids and chenodeoxycholic acid, while secondary bile acids include deoxycholic acid and lithodeoxycholic acid, which are formed through bacterial metabolism in the colon. Bile acids have a hydrophilic head and a hydrophobic tail, which allows them to emulsify dietary fats and form micelles in the small intestine, facilitating their absorption in the intestinal wall.

  • Functions of Bile Acids

Bile acids play an important role in the digestion and absorption of fats in the small intestine. When dietary fat reaches the small intestine, bile acids are secreted into the duodenum, where they emulsify the fat and form micelles. In addition, bile acids act as signaling molecules that regulate metabolic processes, such as glucose and lipid metabolism, by activating nuclear receptors, such as the farneside X receptor (FXR) and the G protein-coupled bile acid receptor 1 (TGR5).

  • Health effects of Bile Acids

Various health problems can arise due to dysfunction in the production or breakdown of bile acids, including liver-related ailments, metabolic disorders, and gastrointestinal disorders. Cholestasis, which obstructs bile flow and leads to harm and scarring of the liver, can be triggered by the accumulation of bile acids within the liver. Dysbiosis, resulting from changes in the composition of bile acids and gut microbiota, may ultimately lead to inflammatory bowel disease (IBD), such as Crohn's disease or ulcerative colitis. Therefore, targeting bile acid synthesis and metabolism may offer a promising therapeutic approach for treating gastrointestinal and liver-related conditions.

Benefits of Bile Acids From BOC Sciences

  1. With both mass production and customizable manufacturing capabilities, BOC Sciences can tailor production to meet our clients' needs while ensuring timely delivery.
  2. BOC Sciences prides itself on providing bile acid products that meet our clients' demands for purity and quality within the field of drug discovery and development.
  3. Our rigorous quality control measures at BOC Sciences means that our manufacturing process adheres to the highest standards of quality with every product.
  4. BOC Sciences offers a variety of packaging options and sizes, providing convenience for our clients' storage and handling needs.
  5. Our broad spectrum of bile acid products, available in various types and sizes, caters to the diverse research purposes and requirements of our clients at BOC Sciences.

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