Phosphatidylglycerol (PG)

BOC Sciences has a specialized liposome technology platform dedicated to providing the most complete solution for liposome drug development services for the pharmaceutical/biotechnology, cosmetic, and nutritional supplement industries. We provide high-quality phosphatidylglycerol.

Definition of Phosphatidylglycerol

Phosphatidylglycerol (PG) is a phospholipid present in lung surfactants. PG is negatively charged due to the polar phosphate group. The overall molecule is also electronegative. Its basic structure is L-glycerol-3-phosphoric acid backbone with saturated or unsaturated fatty acids connected by ester bonds at the 1 and 2 positions, and glycerol and phosphoric acid form monoesters.

Fig. 1 (a) Phosphatidylglycerol and (b) corresponding head group fragment. (Chauhan VM, 2017)

Complete Dissolution of Phosphatidylglycerol

Add a little water to the organic solvent such as methanol or ethanol used, about 0.1%~1% of the total solvent volume (the specific addition amount is subject to the experiment), and then with a high temperature (around the phase transition temperature) water bath ultrasonic to dissolve completely.

Advantages of Phosphatidylglycerol

• Negative charge on the surface of the particles prevents interparticle aggregation and makes the formulation more stable
• Negatively charged particles are easier to deliver across membranes

How to Get Phosphatidylglycerol

• Extraction
• Chemical synthesis
• Biosynthesis

Our Advantages

• Manufacturing process in compliance with GMP requirements
• High-quality lipid raw materials
• Strict quality inspection and quality control
• The most competitive price in the entire network

Reference

1. Chauhan VM; et al. The physicochemical fingerprint of Necator americanus. PLoS Negl Trop Dis. 2017 Dec 7; 11(12): e0005971.