Anionic liposomes show greater stability in solution. Compared with neutrally charged liposomes, anionic liposomes have a lower degree of aggregation. Compared with cations, the endocytosis of anionic liposomes is enhanced.
Materials for liposomes
The composition of liposomes includes neutral phospholipids, negative charged phospholipids, positive-charged lipids, stigmasterol and its glucoside and cholesterol.
The nano-liposomal vector is a novel and effective gene delivery system where liposomes can carry plasmid DNA when combined with nanomaterials. The principle of action is that amino groups affected by pH in the molecular structure can neutralize negative charges of DNA and form a relatively small plasmid DNA.
Clodronate molecules are encapsulated in small liposomes, which have excellent activity, physical and chemical stability, and are easy to use and handle.
Encapsulating ATP in liposomes can prevent extracellular enzymatic hydrolysis, increase ATP circulation time, and enhance its intracellular permeability, which can significantly improve its effectiveness.
Cationic liposomes are the core components of nanoparticles, with a common structure of a positively charged head group and one or two hydrophobic tail regions made of hydrocarbon chains or steroid structures.