Phosphatidylethanolamine (PE)

BOC Sciences has a specialized liposome technology platform dedicated to providing the most complete solution for liposome drug development services for the pharmaceutical/biotechnology, cosmetic, and nutritional supplement industries. We provide high-quality phosphatidylethanolamines.

Introduction of Phosphatidylethanolamine

Phosphatidylethanolamine (PE) or 1,2-diacyl-sn-glycero-3-phosphoethanolamine, also known as ceruloplasmin, is one of the important phospholipids that make up biological membranes. Among the phospholipids present in biology, PE is second only to lecithin in content, and in E. coli it accounts for about 80% of the total phospholipids. PE mainly exists in the brain, nerves, microorganisms and soybeans, and plays an important role in signal transduction and life-sustaining functions.

Properties of Phosphatidylethanolamine

• Small head group
• Unsaturated PE is easy to form non-bilayer structure - form hexagonal phase (preparation of special liposomes)

Biosynthetic Pathway of Phosphatidylethanolamine

• CDP-ethanolamine pathway, also known as the Kennedy pathway
• PSD pathway of phosphatidylserine (PS) decarboxylation
• Acylation of Lysophosphatidylethanolamine (LPE)
• Base change reaction of other glycerophospholipid polar groups

Fig. 1 Synthesis of PE via the two major pathways in cells, the Kennedy pathway (ER) and the PSD reaction (mitochondria). (Patel D, 2017)

Application of Phosphatidylethanolamine

• PE is mainly used as an emulsifier and a liposome carrier material in pharmaceuticals for the manufacture of emulsions and liposomes.
• PE has an antioxidant effect, but due to its high price, it is rarely used as an antioxidant.

Our Advantages

• Manufacturing process in compliance with GMP requirements
• High-quality lipid raw materials
• Strict quality inspection and quality control
• The most competitive price in the entire network

Reference

1. Patel D; et al. Ethanolamine and phosphatidylethanolamine: partners in health and disease. Oxid Med Cell Longev. 2017; 2017: 4829180.