Doxorubicin Liposomal

BOC Sciences is committed to providing high-quality Doxorubicin liposomal products for experimental research purposes such as chemotherapy-related cellular experiments and experimental animal injections. Our Liposomal Doxorubicin product formulations are continuously optimized by experienced experts and can be selected according to the project requirements, enabling you to enhance your R&D productivity.

What is Doxorubicin Liposomal?

Doxorubicin

Doxorubicin, also known as Caelyx, is a chemotherapy drug used clinically to treat cancers such as breast cancer, bladder cancer, Kaposi's sarcoma, lymphoma, and acute lymphoblastic leukemia. It is an anthracycline, which works by interfering with the activity of topoisomerase 2, a topoisomerase enzyme that is required for the division and growth of cancer cells, thereby destroying the tumor.

Figure 1. Chemical structural formula of Doxorubicin.

Doxorubicin Liposomal

The structure of Doxorubicin liposomes, which encapsulate Doxorubicin in tiny spheres of liposomes, grows the ability of Doxorubicin to stay in the bloodstream longer, allowing more of the drug to reach the cancer cells more efficiently.

Figure 2. Modifications of PEGylated liposomal doxorubicin (PLD) surface. (K, Aloss.; et al, 2023)

• Antibody-Conjugated Doxorubicin Liposome

Antibodies are common molecules used for targeted drug delivery due to their high specificity and affinity. They have been used for functionalization of different liposomes, including Doxorubicin lipids. This strategy combines the advantages of liposomal Doxorubicin, including improved drug delivery and reduced side effects, with the specificity of antibodies to more precisely target cancer cells.

• Peptide-Conjugated Doxorubicin Liposome

Synthetic peptides as targeting ligands have several advantages over antibodies due to their small size, which enhances their penetration and distribution. In addition, unlike antibodies, peptides are not immunogenic, which makes them a more suitable method for liposomal modification of Doxorubicin.

• Aptamer-Conjugated Doxorubicin Liposome

Aptamers, which are short sequences of single-stranded DNA or RNA, are a promising tool for active targeting to overcome the difficulties encountered by antibody-based systems to tissues due to lack of immunogenicity, simplicity of preparation and handling, and small size for better penetration. The aptamer is usually affixed to a PEG strand and then inserted into Doxorubicin liposomes.

• Carbohydrates-Conjugated Doxorubicin Liposome

Carbohydrates are a common class of molecules used for liposome decoration. In the modification of Doxorubicin liposomes, carbohydrates, such as sugars or sugar-like molecules, are predominantly attached to the surface of liposomes encapsulating Doxorubicin. This binding is intended to enhance the selectivity of drug delivery to cancer cells. Binding of carbohydrates to the surface of liposomes can specifically target cancer cells that overexpress certain carbohydrate binding proteins or receptors. Commonly used carbohydrates include folic acid, mannose, galactose and hyaluronic acid.

• CPE-Conjugated Doxorubicin Liposome

Caco-2 cell-penetrating peptide (CPE) derived from a specific cell line (Caco-2 cells) is a cell-penetrating peptide designed to enhance cellular uptake of compounds. CPE is an agent that can attach to nanoparticles and facilitate their passage across cell membranes and other cellular barriers in an ATP-dependent and independent manner. In particular, CPEs have positively charged amino acids, which help them cross negatively charged cell membranes.CPEs can have peptide or non-peptide properties.

• Thermosensitive Liposomal Doxorubicin

Thermosensitive Liposomal Doxorubicin is a special formulation of Doxorubicin encapsulated in liposomes with the unique property of becoming more permeable at elevated temperatures. Thermosensitive liposomal Doxorubicin is usually used in combination with heat therapy. When exposed to localized high temperatures, the liposomes undergo a phase change and become more permeable. This property allows for controlled drug release, thereby enhancing the therapeutic effect of the drug. The liposomes in this formulation are designed to be sensitive to temperature changes.

• pH-Sensitive Doxorubicin Liposome

The tumor microenvironment (TME) has a lower pH (pH=6.5-6.8) compared to normal tissue (pH=7.4). In particular, the pH of lysosomes is more acidic (pH=5-6). These pH differences can be used to develop acid-responsive Doxorubicin liposome nanoparticles. pH sensitivity can be achieved by including pH-sensitive lipids, pH-sensitive peptides, or pH-sensitive polymers.

Applications of Doxorubicin Liposomal

Broad-spectrum Cancer Research: Doxorubicin, as a chemotherapeutic reagent with the ability to inhibit the division of cancer cells, is widely used in preclinical studies of various tumors by direct injection.

Cardiovascular Disease Research: Since Doxorubicin liposomes can attenuate the cardiotoxicity of Doxorubicin, it may be used to study the mechanism of cardiovascular disease as well as develop therapeutic strategies.

Inflammatory and Immune Diseases Research: Doxorubicin liposomes may be utilized in the research and development of new approaches for the treatment of inflammatory and autoimmune diseases. Liposomes can help deliver drugs precisely to the site of inflammation and reduce systemic toxicity.

Liver Disease Research: Liposomal delivery systems may help improve Doxorubicin distribution in liver tissue. Thus, Doxorubicin liposomes may be used to study liver diseases such as liver fibrosis or liver cancer.

Drug Delivery Development: Adriamycin liposomes can be used as a model to study drug delivery systems and nanotechnology, helping to advance improved drug delivery, increase bioavailability, and reduce drug toxicity.

Advantages of BOC Sciences' Doxorubicin Liposomal

BOC Sciences offers a wide range of Doxorubicin liposomal products, including not only polyethylene glycolized non-polyethylene glycolized Doxorubicin liposomes, but also Doxorubicin liposomes affixed with various antibodies, proteins, peptides surface-reactive ligands.

BOC Sciences also offers customized Doxorubicin liposome products that can be tailored to meet the specific modifications, formulations or carrier ratios of the liposome type required for your project.

BOC Sciences maintains strict quality control and has optimized efficient separation and purification strategies to ensure that you receive Doxorubicin liposomes of high purity.

For more custom services about our Doxorubicin liposomes, please feel free to contact us.

Reference

1. K, Aloss.; et al. Modifications of PEGylated liposomal doxorubicin (PLD) surface. Pharmaceutics. 2023, 15(3): 893.