Phosphatidylserine (PS)

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BOC Sciences has a specialized liposome technology platform dedicated to providing the most complete solution for liposome drug development services for the pharmaceutical/biotechnology, cosmetic, and nutritional supplement industries. We provide high-quality phosphatidylserine.

Definition of Phosphatidylserine

Phosphatidylserine (PS), a member of the phospholipid family, is the only phospholipid that regulates the functional state of key cell membrane proteins. Usually, PS refers to a group of compounds rather than a single ingredient, because the lipid acetyl residues of products from different raw material sources vary greatly.

Structure of Phosphatidylserine

PS consists of three parts: the hydrophilic glycerol backbone as the head, and the lipophilic groups of two longer hydrocarbon chains as the tail.

The head consists of three groups: a serine residue bonded to a phosphate residue and then attached to the hydroxyl group of the glycerol at the C-3 position.

The other two hydroxyl groups of glycerol respectively form esters with fatty acids to form tails. Fatty acids at the C-2 position of glycerol generally have longer carbon chains and more unsaturated bonds than fatty acids at the C-1 position.

The structure of phosphatidylserine  Fig. 1 The structure of phosphatidylserine (Cassilly CD, 2018)

Sources of Phosphatidylserine

PS is present in the biofilms of all animals, higher plants and microorganisms. PS in the human body is mainly concentrated in the brain, accounting for about 15% of the total phospholipids in the brain. Both meat and fish contain PS, and the content of PS in the brain or internal organs (such as the liver and kidney) is higher. Dairy products and vegetables (except white beans) contain very little PS.

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  1. Cassilly CD; et al. PS, It's Complicated: The Roles of Phosphatidylserine and Phosphatidylethanolamine in the Pathogenesis of Candida albicans and Other Microbial Pathogens. J Fungi (Basel). 2018 Feb 20; 4(1): 28.

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