Liposomal-gold Nanoparticles

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BOC Sciences provides the highest quality liposomal-gold nanoparticles. Our liposomes are prepared by experienced formulators using defined quality lipids that can significantly enhance your R&D productivity and reliability.

Liposomal-gold Nanoparticles

According to structures, gold nanoparticles are divided into gold nanospheres, gold nanostars, gold nanorods, gold nanocages, etc. In the field of biochemistry and pharmacology, gold nanoparticles are advanced due to their non-toxicity, biocompatibility, stability to various conditions, and simple preparation processes. Gold nanoliposome complexes are one of the most widely studied nanomaterials today. It can be used as a carrier to deliver a wide range of drugs to target sites effectively while eliminating the existing toxic effects caused by anti-cancer drugs.

Researchers synthesized lipid bilayer-protected gold nanoparticles (DODAB-AuNPs), which deliver plasmid DNA to human kidney epithelial cells (HEK293) by reducing chloroauric acid with sodium borohydride and using cationic liposome dioctadecyldimethylammonium bromide (DODAB) as a protectant under stirring conditions at room temperature. The transfection efficiency of DODAB-AuNPs was 4-fold higher than that of cationic liposomes alone and has successfully achieved an equivalent efficiency of commercial liposomes (Lipotap).

Beyond DODAB-AuNPs, researchers also modified folic acid (FA), small molecules targeting cancer cells, onto synthesized nano gene carriers to synthesize GDD-FA nano gene carriers that could effectively reach cancer cells. Experimentally, relatively low transfection efficiency was observed with GDD-FA/DNA in lung cancer cells (A549, folic acid receptor-negative cells). In contrast, with breast cancer cells (MCF-7, FA receptor-positive cells), liposomal gold nano gene carrier modified with 2.5% FA demonstrated an 85% transfection efficiency. These results prove that GDD-FA/DNA carriers were beneficial for gene therapy in tumor cells that overexpress folate receptors.

Preparation of GDD-FA/DNA and GDD-FA-RhB/DNA complexes (A); in vitro and in vivo transfection applications of GDD-FA/DNA (B) Fig. 1 Preparation of GDD-FA/DNA and GDD-FA-RhB/DNA complexes (A); in vitro and in vivo transfection applications of GDD-FA/DNA (B)

Our Liposomal-gold Nanoparticles Products

  • Liposomal-gold nanoparticles
  • Liposomal-gold nanoparticles containing FAs
  • Other modified liposomal-gold nanoparticles

Advantages

  • Good biocompatibility
  • Good physical and chemical properties
  • High gene transfection efficiency
  • High target cell recognition
  • Low cytotoxicity

Application

  • Targeted drug delivery
  • Tumor photothermal therapy
  • Gene delivery

References

  1. Li D; et al. The effect of nocodazole on the transfection efficiency of lipid-bilayer coated gold nanoparticles. Biomaterials. 2009 Mar; 30(7): 1382-8.
  2. Du B; et al. Lipid-coated gold nanoparticles functionalized by folic acid as gene vectors for targeted gene delivery invitro and invivo. ChemMedChem. 2017 Nov 8; 12(21): 1768-1775.
※ Only for research. Not suitable for any diagnostic or therapeutic use.

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Anionic Liposomes

Materials for liposomes

Nano-Liposomes

Clodronate Liposomes

ATP-Liposome

Cationic Liposomes