Metal Chelating Liposomes

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BOC Sciences, as a liposome specialist, is committed to providing you with a range of high quality metal chelating liposomes to assist you in your research and applications in the fields of drug delivery, diagnostics and therapeutics. With our state-of-the-art laboratory equipment and GMP-grade manufacturing capabilities, both conventional and customized metal chelated liposomes are available at BOC Sciences.

What are Metal Chelating Liposomes?

What is chelation?

The process of chelation is primarily the binding of ions and molecules to metal ions and involves the formation or presence of two or more individual ligand bonds between a multidentate (multi-bonded) ligand and a single central metal atom. Chelation results in the formation of stable ring structures that are used for a variety of purposes, such as providing nutritional supplements, as a contrast agent in magnetic resonance imaging scans, as homogeneous catalysts in manufacturing processes, and to aid in the removal of metals in chemical water treatment.

Figure 1. Ring structure for chelation.

The Overview of Metal Chelating Liposomes

Metal chelating liposomes are a special class of liposomes that contain metal chelating agents as well as appropriate lipid components and have many applications in biomedical and nanotechnology fields.

Metal chelating liposome. Figure 2. Metal chelating liposomes. (D, Lam.; et al, 2018)

There are some common metal ions used for chelating liposomes.

Iron (Fe): Iron chelating liposomes are used in therapeutic studies for iron overload disorders such as thalassemia and hemochromatosis.
Copper (Cu): Copper chelating liposomes are used to alleviate copper toxicity by binding and reducing the concentration of copper ions in the body.
Cobalt (Co): Cobalt chelated liposomes may be used in medical imaging, especially MRI. they can encapsulate cobalt ions to act as an MRI contrast agent, improving image quality.
Manganese (Mn): Manganese chelated liposomes may also be used as MRI contrast agents to enhance the contrast of MRI images.
Zinc (Zn): Zinc chelated liposomes may be used in biomedical research to manage zinc concentration and distribution, especially in neurodegenerative disease research.
Cadmium (Cd): Cadmium chelated liposomes can be used to remove cadmium contamination from water.
Other Heavy Metals: Metal chelating liposomes can also be used to remove or monitor other heavy metals such as lead, mercury, nickel and lanthanum.

There are some common metal complexing agents.

EDTA (ethylenediamine tetraacetic acid) can form strongly stabilized complexes with a wide range of metal ions. It is used in the laboratory for titrimetric analysis, as a complex preservative in food and cosmetics, and in medicine for the treatment of metal poisoning.
DMSA (dimercaptosuccinic acid) is commonly used to bind toxic metals such as lead.
Deferoxamine is commonly used to bind to excess iron in the body and promote its elimination.
Deferiprone is commonly used to bind to iron.
Desferrioxamine B (Deferrobus): Deferiprone B is used in industrial applications to remove iron and other heavy metals from water and other solutions. It is used in the treatment research of iron poisoning.
Cyclohexanediamine tetraacetic acid (CDTA) has excellent complexing ability for lead and other heavy metals and is used in applications with chemical analysis.
HEDTA (N- (2-hydroxyethyl) ethylenediamine triacetic acid) is used for heavy metal complexation.

Advantages of BOC Sciences' Metal Chelating Liposome

BOC Sciences professional team consists of experienced professionals dedicated to the production and research of best-in-class metal chelated liposome products to ensure product quality and consistency.

BOC Sciences metal chelate liposome product range is diverse and allows for individual customization to meet the unique needs of our customers.

Using the purest raw materials, BOC Sciences metal chelated liposomes meet and exceed the industry's high standards for quality and purity.

BOC Sciences' after-sales service offers a comprehensive approach that includes technical assistance, quality assurance and exclusive offers to ensure that our valued customers receive the highest level of assistance.

For more custom services about our metal chelating liposomes, please feel free to contact us.

Reference

D, Lam.; et al. Effects of chelator lipids, paramagnetic metal ions and trehalose on liposomes by solid-state NMR. Solid State Nuclear Magnetic Resonance. 2018, 94: 1-6.