Liposome-based Wound Dressing Development Service

• Custom Liposomal Gel Formulation Service: Leveraging our proprietary technologies, we formulate liposomal gels optimized for topical wound care. Our gels offer superior bioadhesion, controlled therapeutic release, and moisture retention properties—critical for creating high-performance wound dressings. We can encapsulate antimicrobials, anti-inflammatory agents, peptides, or growth factors within these biocompatible liposomal gel matrices.
• Unilamellar and Multilamellar Vesicle Production: Tailored liposome structures, including small unilamellar vesicles (SUVs, 20–100 nm), large unilamellar vesicles (LUVs, 100–500 nm), and multilamellar vesicles (MLVs), to suit varying drug release profiles in wound healing.
• Surface Functionalized Liposomes: Development of PEGylated liposomes or liposomal targeted modification services to enhance stability, modulate immunological interactions, and facilitate targeted delivery to wound sites.
• Deformable and Elastic Liposomes: For enhanced skin penetration and delivery to deeper tissue layers, we offer preparation of ultradeformable liposomes (e.g., transfersomes) ideal for challenging wound environments.
• Controlled Release Profiles - Intelligent Responsive Liposome: Fine-tuning of lipid compositions and lamellarity to achieve sustained or stimuli-responsive release of actives across various wound environments (e.g., pH-responsive, temperature-sensitive lipsomes).
• Liposomal Encapsulation of Therapeutic Agents:

(1) Antimicrobials (e.g., silver ions, antibiotics) for infection control
(2) Growth Factors (e.g., EGF, FGF) to stimulate tissue regeneration
(3) Anti-inflammatory Compounds (e.g., curcumin, corticosteroids) to manage wound site inflammation
(4) Oxygen-Carrying Agents for hypoxic wound environments

Recognizing the critical impact of lipid quality on product performance, BOC Sciences offers a wide selection of high-purity lipids and functional lipid derivatives designed specifically for wound dressing development:

• High-purity Phospholipids: We provide a broad selection of cGMP grade phospholipids such as phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidylserine (PS), and sphingolipids critical for constructing stable and functional liposome bilayers.
• Functionalized Lipid Derivatives: Access to lipid derivatives such as DSPE-PEG2000, cholesterol sulfate, and cationic lipids to modulate liposome properties like circulation time, charge, and membrane fluidity.
• Sterile and Endotoxin-controlled Lipids: For sensitive wound applications, we supply sterile-filtered and endotoxin-tested lipids ensuring compatibility with cGMP-grade standards.

All lipids are supplied with comprehensive characterization data including HPLC purity, endotoxin levels, and stability profiles, facilitating seamless integration into custom liposome formulation services.

Our capabilities include the development of a wide range of dressing formats that integrate liposomes seamlessly into the structure of the final product. Here are some of the key areas of focus for liposome-embedded dressing fabrication:

• Hydrogel-based Liposome Dressings: Hydrogels are ideal for wound care due to their moisture-retentive properties, keeping the wound hydrated, preventing tissue dehydration, and promoting cell migration. By incorporating liposomes into hydrogels, BOC Sciences enhances the bioavailability of active ingredients, improving therapeutic effects. Liposomes are embedded in hydrogels like alginate, chitosan, and hyaluronic acid, creating a biocompatible matrix that ensures a moist environment conducive to healing. These liposome-embedded hydrogels provide sustained release of active ingredients like growth factors, antimicrobial agents, or anti-inflammatory drugs, reducing the need for frequent dressing changes. We offer hydrogel customization for enhanced adhesion, flexibility for joint wounds, and microbial resistance.
• Electrospun Nanofiber Dressings: Nanofiber mats provide high surface area, breathability, and structural support, making them ideal for drug delivery. Liposome-loaded electrospun nanofibers improve mechanical properties while enabling controlled release of therapeutic agents. The increased surface area of these mats allows for a higher loading capacity of active ingredients, improving their contact with the wound bed and promoting faster healing. The electrospinning process creates a porous yet strong mesh that mimics the natural extracellular matrix, aiding tissue regeneration. Liposomes are evenly distributed, ensuring uniform release and effect. These dressings can be customized for specific wound types like chronic diabetic ulcers or burns by adjusting the composition of nanofibers and liposomes.
• Liposome-Embedded Film and Membrane Systems: Liposome-embedded films and membranes offer excellent moisture retention and act as a barrier to external contaminants, making them suitable for surgical wounds, post-operative care, or severe abrasions. The thin, flexible films are easy to apply and promote a moist healing environment. Liposomes embedded within the films release their active agents gradually, supporting wound healing over time. Collagen-based matrices, mimicking skin properties, can deliver active agents like collagenase inhibitors, growth factors, and antimicrobial peptides, aiding tissue repair and reducing infection risks. Liposome-infused films can be designed with enhanced elasticity, making them ideal for areas with constant movement, ensuring long-term wound management.
• Sprayable Liposome Formulations: For hard-to-reach wound sites, sprayable liposome formulations offer a non-invasive way to apply liposome-embedded solutions. Particularly useful for large burns or irregular wounds, these formulations ensure even coverage, releasing therapeutic agents directly onto the affected area to promote faster healing and reduce infection. We offer both hydrophilic and hydrophobic formulations, tailored to the wound's characteristics, such as moisture content or barrier protection needs. The quick-drying, non-toxic film formed by sprayable formulations reduces discomfort and prevents contamination.

Precision characterization is central to ensuring the functional integrity of liposome-based wound dressings. Our advanced analytics include:

• Dynamic Light Scattering (DLS) for particle size and polydispersity
• Zeta potential measurements for surface charge profiling
• Transmission Electron Microscopy (TEM) and Cryo-TEM imaging for vesicle morphology validation
• Encapsulation efficiency and loading capacity assays
• In vitro release kinetics studies under simulated wound conditions (e.g., simulated wound fluid models)
• Cytocompatibility and hemocompatibility assays according to cGMP standards

BOC Sciences supports early-phase biological evaluation to accelerate time-to-decision making:

• In vitro cell proliferation and migration assays (fibroblast, keratinocyte models)
• Antimicrobial efficacy testing against common wound pathogens (e.g., S. aureus, P. aeruginosa)
• Ex vivo skin permeation and retention studies
• In vitro inflammatory cytokine modulation studies