Liposomal Formulation Development

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We provide services for liposome formulations development for various pharmaceutical active ingredients such as oligonucleotides, small molecules, proteins, and vaccine antigens, to meet the growing outsourcing requirements of pharmaceutical/biotechnology, cosmetics, and nutritional supplements industry for formulation development.

What Are Liposomes?

Liposomes are spherical vesicles with internal cavities and composed of one or more phospholipid bilayers. Their structural components are phospholipids or synthetic amphiphilic combined with cholesterol and other sterols, which can affect membrane permeability. Liposomes can encapsulate hydrophilic or lipophilic molecules. Their applications are now well established in various fields such as medicine, biomolecules, and gene delivery, and have been studied as DDS (drug delivery system) to enhance treatment safety and efficacy of the agent.

Particle Type	Composition	Active Ingredients
Conventional liposomes	Neutral and or negatively charged phospholipids Cholesterol	Nucleic acid Peptides and proteins Small molecules Imaging contrast agents
Cationic liposomes	Cationic lipids	Nucleic acid（mainly）
Nucleic acid lipid nanoparticles (LNPs)	Hybrid particles made of lipids and polymers	Nucleic acid Peptides and proteins
PH sensitive liposomes	Phospholipids such as Phosphatidylethanolamine, Dioleoyl phosphatidylethanolamine with either CHEMS1or OA2	Nucleic acid Peptides and proteins
Magnetic liposomes	Phosphatidyl choline Cholesterol small amounts of a linear chain aldehyde Colloidal particles of magnetic iron oxide	Nucleic acid Peptides and proteins Small molecules Imaging contrast agents
Thermally sensitive liposomes (TSLs)	DPPC, MSPC have been used in the preparation of liposomes to develop temperature-dependent releases
Polymer NPs	Poly-lactides (e.g. PLGA) Block copolymers (e.g. PEG-b-PLGA) Polysaccharides (e.g. chitosan, cellulose)
Emulsions	Triolein/POPC Oil/surfactant	Small molecules Imaging contrast agents
Organic/Inorganic NPs	Lipids Noble metal NPs Rare earth metals III-V semiconductors	Imaging contrast agents

Development Process of Liposomal Formulation

Provide free technical advice on liposomes, and assistance in liposome design
Custom lipid synthesis for your formula
Make custom liposome formulations to meet your specifications

Our Liposome Formulation Capabilities

BOC Sciences is your ideal partner for developing liposome products. We have many years of experience in providing our customers with complex liposome formulations with nucleic acids, proteins, peptides, and small molecules. Our experience with liposomes includes:

Sterile or final disinfection (TS)
Liposomal design and synthesis
- Extrusion manufacturing
- Batch manufacturing
Freeze-drying cycle optimization
Improvements to existing formulas

Why Choose Us?

Formulations of many types of pharmaceutical compounds (siRNA, mRNA, DNA，proteins and peptides, small molecules, antigen, etc.)
Short processing time - One-step preparation using automated equipment
No cross-contamination - Liposomes are produced in disposable autoclaves
Expertise and experienced with hundreds of successful lipid nanoparticle drug development projects
Efficient service delivery
Provide final report detailing the liposomes formulation design and synthesis