Solution
- Liposomal Product Characterization
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Liposome Encapsulation
- Antigens Encapsulation
- Antioxidants Encapsulation
- Drugs Encapsulation
- Enzymes Encapsulation
- Liposomal Encapsulation Services: DNA
- Liposomal Encapsulation Services: Labeling Agents
- Liposomal Encapsulation Services: miRNA
- Liposomal Encapsulation Services: Oligonucleotide
- Liposomal Encapsulation Services: Proteins & Peptides
- Liposomal Encapsulation Services: siRNA
- mRNA Encapsulation
- siRNA, miRNA, DNA, Proteins Encapsulation
- Vitamins & Minerals Encapsulation
- Formulation Solutions
- Custom Liposomes
- Process Development and Scale-up
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Online InquiryLiposomal Formulation Development
Online InquiryWe provide services for liposome formulations development for various pharmaceutical active ingredients such as oligonucleotides, small molecules, proteins, and vaccine antigens, to meet the growing outsourcing requirements of pharmaceutical/biotechnology, cosmetics, and nutritional supplements industry for formulation development.
What Are Liposomes?
Liposomes are spherical vesicles with internal cavities and composed of one or more phospholipid bilayers. Their structural components are phospholipids or synthetic amphiphilic combined with cholesterol and other sterols, which can affect membrane permeability. Liposomes can encapsulate hydrophilic or lipophilic molecules. Their applications are now well established in various fields such as medicine, biomolecules, and gene delivery, and have been studied as DDS (drug delivery system) to enhance treatment safety and efficacy of the agent.
| Particle Type | Composition | Active Ingredients |
|---|---|---|
| Conventional liposomes | Neutral and or negatively charged phospholipids Cholesterol | Nucleic acid Peptides and proteins Small molecules Imaging contrast agents |
| Cationic liposomes | Cationic lipids | Nucleic acid（mainly） |
| Nucleic acid lipid nanoparticles (LNPs) | Hybrid particles made of lipids and polymers | Nucleic acid Peptides and proteins |
| PH sensitive liposomes | Phospholipids such as Phosphatidylethanolamine, Dioleoyl phosphatidylethanolamine with either CHEMS1or OA2 | |
| Magnetic liposomes | Phosphatidyl choline Cholesterol small amounts of a linear chain aldehyde Colloidal particles of magnetic iron oxide | Nucleic acid Peptides and proteins Small molecules Imaging contrast agents |
| Thermally sensitive liposomes (TSLs) | DPPC, MSPC have been used in the preparation of liposomes to develop temperature-dependent releases | |
| Polymer NPs | Poly-lactides (e.g. PLGA) Block copolymers (e.g. PEG-b-PLGA) Polysaccharides (e.g. chitosan, cellulose) | |
| Emulsions | Triolein/POPC Oil/surfactant | Small molecules Imaging contrast agents |
| Organic/Inorganic NPs | Lipids Noble metal NPs Rare earth metals III-V semiconductors | Imaging contrast agents |
Development Process of Liposomal Formulation
- Provide free technical advice on liposomes, and assistance in liposome design
- Custom lipid synthesis for your formula
- Make custom liposome formulations to meet your specifications
Our Liposome Formulation Capabilities
BOC Sciences is your ideal partner for developing liposome products. We have many years of experience in providing our customers with complex liposome formulations with nucleic acids, proteins, peptides, and small molecules. Our experience with liposomes includes:
- Sterile or final disinfection (TS)
- Liposomal design and synthesis
- Extrusion manufacturing
- Batch manufacturing
- Freeze-drying cycle optimization
- Improvements to existing formulas
Why Choose Us?
- Formulations of many types of pharmaceutical compounds (siRNA, mRNA, DNA，proteins and peptides, small molecules, antigen, etc.)
- Short processing time - One-step preparation using automated equipment
- No cross-contamination - Liposomes are produced in disposable autoclaves
- Expertise and experienced with hundreds of successful lipid nanoparticle drug development projects
- Efficient service delivery
- Provide final report detailing the liposomes formulation design and synthesis