Name: Liposomal Encapsulation Services: Probiotics & Prebiotics
Brand: BOC Sciences

Introduction to Our Liposomal Probiotics & Prebiotics Encapsulation Services

In the pursuit of enhancing the bioavailability and functionality of probiotics and prebiotics, liposomal encapsulation has emerged as a pivotal preclinical formulation strategy. At BOC Sciences, we specialize in cutting-edge liposome technologies that provide unparalleled protection, targeted delivery, and sustained release capabilities for microbial and oligosaccharide-based compounds. Leveraging over two decades of biochemical expertise, our liposomal encapsulation platform is meticulously designed to support researchers and product developers in achieving formulation stability, gastrointestinal survivability, and targeted release in preclinical applications.

How to Get Started with Us?

Reach out via our online inquiry form or direct email to share your initial project concept and encapsulation needs.
Schedule a consultation with our scientific team to define strain types, formulation targets, and delivery expectations.
We will perform a preliminary technical assessment to evaluate project suitability, risks, and formulation complexity.
A detailed proposal will be provided, including encapsulation strategy, timelines, QC checkpoints, and cost estimates.
Once both sides agree on project scope and terms, a service agreement is executed, and we initiate the experimental workflow.

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What is Encapsulation of Probiotics & Prebiotics?

Liposomal encapsulation of probiotics and prebiotics involves the integration of these bioactives into lipid bilayer vesicles to enhance their stability and functionality. Unlike conventional delivery methods, liposomes provide a biocompatible, phospholipid-based structure that shields encapsulated agents from harsh environmental conditions such as pH fluctuations, enzymatic degradation, and oxygen exposure. This encapsulation strategy significantly improves survival rates during gastrointestinal transit and enhances systemic bioactivity in controlled environments.

Probiotics, typically live microbial strains such as Lactobacillus or Bifidobacterium, benefit from liposomal shielding to preserve their viability during storage and in simulated gastrointestinal conditions.
Prebiotics, such as inulin, fructooligosaccharides (FOS), or galactooligosaccharides (GOS), when liposomally encapsulated, show improved solubility, controlled release, and synergistic effects in co-delivery systems.

Liposomes encapsulated with probiotics and prebiotics. (BOC Sciences Original) Schematic structure of liposomes loaded with probiotics and prebiotics. (BOC Sciences Original)

Comprehensive Services for Liposomal Probiotics & Prebiotics Encapsulation

BOC Sciences delivers scientifically rigorous and application-driven liposomal encapsulation services tailored specifically for probiotics and prebiotics. Our encapsulation platform is designed to meet the precise requirements of preclinical research, formulation testing, and early-stage product development. The following encapsulation formats and service offerings represent our comprehensive capabilities:

Liposomal Probiotics Encapsulation Services

We offer strain-specific encapsulation solutions for a broad spectrum of probiotic microorganisms, for example:

Lactobacillus spp. (L. acidophilus, L. rhamnosus, L. casei)
Bifidobacterium spp. (B. longum, B. bifidum)
Bacillus spp. (B. coagulans, B. subtilis)
Next-generation probiotics such as Akkermansia muciniphila or Faecalibacterium prausnitzii (strict anaerobes requiring advanced encapsulation strategies)

Key Features of Our Liposomal Probiotic Products:

Gastrointestinal protection: Liposomal barriers dramatically improve survival under simulated gastric conditions (low pH and bile salt exposure).
Enhanced storage stability: Lyophilized or spray-dried liposomal probiotics maintain >90% viability after long-term refrigerated or room-temperature storage.
Controlled release: Phospholipid matrix designs enable intestinal-targeted release triggered by pH, enzymes, or time.

Liposomal Prebiotics Encapsulation Services

We specialize in encapsulating sensitive or poorly soluble prebiotics in lipid-based nanocarriers, including:

Inulin
Fructooligosaccharides (FOS)
Galactooligosaccharides (GOS)
Resistant starches & xylo-oligosaccharides (XOS)
Beta-glucans and plant-derived polysaccharides

Benefits of Our Liposomal Prebiotic Products:

Improved aqueous solubility and dispersibility, critical for formulation in beverages or semi-solids.
Protection against premature fermentation in the upper GI tract, preserving selective fermentation in the colon.
Dual loading capability with probiotics for synbiotic delivery—co-encapsulation of live strains and prebiotic substrates in a single vesicle.

Synbiotic Liposomal Co-Encapsulation Services

BOC Sciences leads in the development of synbiotic liposomal systems that co-encapsulate both probiotic strains and their matching prebiotics in a single nanocarrier.

Advantages of Synbiotic Co-Encapsulation:

Synergistic survival and activation: Encapsulated prebiotics serve as an immediate nutrient source post-release, enhancing colonization.
Stability enhancement: Prebiotics stabilize probiotic viability by buffering osmotic stress and oxidative damage.
Compact dosage design: Enables simplified formulation architecture in product prototypes for preclinical use.

Stability, Compatibility, and Scalability Testing Services

Gastrointestinal Simulation Testing: BOC Sciences performs pH 1.5–7.4 release profiling using USP IV dissolution apparatus or simulated digestion models.
Prebiotic-Probiotic Compatibility Testing: Ensures no antagonistic interactions during storage or encapsulation.
Scalable Production: Capable of microfluidic or high-shear homogenization-based preparation from milligram to gram-scale for animal model testing.

Liposomal Probiotics/Prebiotics Lyophilization Services

To support extended preclinical use, we offer lyophilization of liposomal formulations with customized cryoprotectants:

Preservation of vesicle structure and probiotic viability (>90% retention post-rehydration)
Ready-to-use powder form for reconstitution in aqueous or oil-based delivery systems
Compatible with capsule filling, gel matrices, or direct mixing into semi-solid vehicles

Step-by-Step Process of Liposomal Probiotics & Prebiotics Encapsulation Service

BOC Sciences follows a highly controlled and modularized encapsulation workflow to ensure reproducibility, high encapsulation efficiency, and functional stability of probiotic and prebiotic formulations. Each project is executed with precision and tailored parameters to suit specific biological materials.

1. Project Evaluation & Formulation Strategy

Detailed analysis of the physicochemical properties of target probiotic strains or prebiotic compounds.
Custom formulation blueprint based on desired release profile, vesicle type, and administration route (oral, enteric, etc.).

2. Custom Liposome Preparation

Application of thin-film hydration, reverse-phase evaporation, or microfluidics depending on strain sensitivity and vesicle complexity.
Optimization of lipid concentration, hydration media, and sonication or extrusion conditions.

3. Liposomal Encapsulation & Loading

Passive or active encapsulation of target probiotic/prebiotic using carefully controlled conditions to avoid viability loss or substrate degradation.
Co-encapsulation protocols available for synbiotic formulations.

4. Stabilization & Processing

Optional lyophilization or spray drying with suitable stabilizers (e.g., trehalose, mannitol) to maintain functionality post-processing.
Surface modification (e.g., PEGylation or mucoadhesive coating) available upon request.

5. Quality Control & Characterization

Particle size, polydispersity, and zeta potential analysis by DLS.
Encapsulation efficiency quantified via CFU counts (probiotics) or chromatographic assays (prebiotics).
In vitro release behavior and simulated gastrointestinal stability profiling.

6. Delivery Format & Final Packaging

Flexible output formats including aqueous suspension, dry powder, or semi-solid formulations, designed for direct use in preclinical models.

Benefits of Our Liposomal Probiotics & Prebiotics Encapsulation Service

Unmatched Expertise in Liposome Nanotechnology: Backed by over 20 years of biochemical formulation experience, BOC Sciences delivers cutting-edge liposomal systems with an emphasis on reproducibility, functionality, and regulatory alignment for preclinical research.
One-stop Customized Solutions: Each encapsulation strategy is formulated de novo based on customer targets—no generic recipes or one-size-fits-all solutions.
Advanced Analytical Capabilities: From vesicle size tuning (30–500 nm) to encapsulation efficiency quantification and degradation profiling, our QC pipeline ensures high formulation integrity.
Cross-Disciplinary Support: Integration of microbiology, lipid chemistry, nanomedicine, and delivery science ensures that every project benefits from a robust scientific foundation and strategic formulation decisions.

Applications of Our Liposomal Probiotics & Prebiotics Encapsulation Service

The encapsulation of probiotics and prebiotics in liposomal structures opens up a broad spectrum of commercial and research applications across health-related industries. BOC Sciences' liposomal encapsulation service significantly enhances the functional viability and performance of these bioactives, enabling tailored solutions for demanding delivery environments.

Functional Food and Beverage Industry

Liposomal encapsulated probiotics and prebiotics are increasingly integrated into fortified foods and drinks such as dairy products, fermented beverages, energy bars, and health shots. The liposomal barrier protects sensitive strains from degradation during processing, pasteurization, and shelf storage, ensuring that viable colonies reach the gastrointestinal tract.

Pharmaceutical and Nutraceutical Formulations

In oral dosage forms, liposomal delivery supports targeted and sustained release of probiotic and prebiotic compounds, potentially improving patient compliance and therapeutic outcomes. This is particularly relevant in formulations addressing gut microbiota imbalances, irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), and antibiotic-associated diarrhea.

Pediatric and Geriatric Nutrition

Vulnerable populations such as infants and the elderly benefit from the enhanced stability and reduced gastric irritation provided by liposomal carriers. Liposomal encapsulation enables safer and more palatable administration of probiotics/prebiotics in age-specific nutritional formulations.

Cosmeceuticals and Dermatological Applications

Emerging evidence supports the use of skin-targeted probiotics in managing acne, rosacea, and eczema. Liposomal encapsulation improves the skin permeation and stability of probiotic agents in topical creams, gels, and emulsions, allowing for improved efficacy and controlled release.

Animal Nutrition and Veterinary Supplements

Liposomal delivery systems extend into animal health by enhancing the stability and delivery of probiotics/prebiotics in feed supplements. This promotes gastrointestinal health in livestock, poultry, and companion animals, reducing the need for antibiotic usage and improving feed conversion efficiency.

FAQs – Insights about Our Liposomal Probiotics & Prebiotics Encapsulation Service

Can your liposomal encapsulation service handle strain-specific probiotic formulations? Yes. BOC Sciences supports the encapsulation of strain-specific probiotics, ensuring that the physicochemical characteristics of each microorganism (e.g., oxygen sensitivity, pH tolerance) are preserved. Custom liposomal formulations are optimized to meet the viability and release requirements of each unique strain.
How do you ensure the viability of probiotics during and after liposomal encapsulation? We implement cold-process encapsulation protocols, oxygen-controlled environments, and cryoprotective agents where necessary. Post-encapsulation, we conduct rigorous viability testing (e.g., CFU enumeration, stability assays) to confirm product integrity during storage and shelf life.
Are your liposomal encapsulated products suitable for inclusion in functional foods or beverages? Yes. Our encapsulated products are designed to maintain structural stability and microbial viability under various food processing conditions, including pasteurization and freeze-drying. Liposomal probiotics and prebiotics can be seamlessly integrated into a range of matrices without compromising efficacy.
What release profiles can be achieved with your liposomal encapsulation system? Depending on the lipid composition and surface modifications, we can engineer immediate-release, sustained-release, or colon-targeted delivery systems. These profiles are validated through in vitro simulated digestion models and, if required, in vivo preclinical studies.
How do you ensure the reproducibility and consistency of liposomal formulations across batches? BOC Sciences implements advanced liposome manufacturing technologies including microfluidics and high-pressure homogenization, alongside stringent batch-to-batch quality control protocols (e.g., particle size distribution, zeta potential, encapsulation efficiency).

For advanced liposomal encapsulation of probiotics and prebiotics tailored to your preclinical research goals, contact BOC Sciences—where innovative delivery meets uncompromised scientific rigor.

Liposomal Encapsulation Services: Probiotics & Prebiotics