KRN7000
| Catalog Number | BL-M000897 |
| CAS Number | 158021-47-7 |
| Description | KRN7000 is a synthetic analog of α-galactosylceramide and the marine natural product agelasphin. It is a specific ligand for human and mouse NKT cells and remains the best studied ligand of the lipid-binding MHC class I-like protein CD1d. It protects against LPS-induced shock and displays potent antitumor activity in various in vivo models. |
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| IUPAC Name | N-[(2S,3S,4R)-3,4-dihydroxy-1-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoctadecan-2-yl]hexacosanamide |
| Synonyms | a-Gal-Cer N-[(1S,2S,3R)-1-[(a-D-Galactopyranosyloxy)methyl]-2,3-dihydroxyheptadecyl]hexacosanamide KRN7000 |
| Molecular Weight | 858.32 |
| Molecular Formula | C50H99NO9 |
| Boiling Point | 939.8°C at 760 mmHg |
| Melting Point | 27°C |
| Purity | >99% |
| Density | 1.04 g/cm3 |
| Appearance | White Solid |
| Shelf Life | 1 Year |
| Storage | Store at -20°C |
| Percent Composition | C 69.97%, H 11.63%, N 1.63%, O 16.78 |
| Canonical SMILES | CCCCCCCCCCCCCCCCCCCCCCCCCC(=O)NC(COC1C(C(C(C(O1)CO)O)O)O)C(C(CCCCCCCCCCCCCC)O)O |
| InChI | InChI=1S/C50H99NO9/c1-3-5-7-9-11-13-15-17-18-19-20-21-22-23-24-25-26-27-29-31-33-35-37-39-45(54)51-42(41-59-50-49(58)48(57)47(56)44(40-52)60-50)46(55)43(53)38-36-34-32-30-28-16-14-12-10-8-6-4-2/h42-44,46-50,52-53,55-58H,3-41H2,1-2H3,(H,51,54)/t42-,43+,44+,46-,47-,48-,49+,50-/m0/s1 |
| InChI Key | VQFKFAKEUMHBLV-BYSUZVQFSA-N |
※ Please be kindly noted products are not for therapeutic use. We do not sell to patients.
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