GL67
| Catalog Number | BL-M000107 |
| CAS Number | 179075-30-0 |
| Description | Genzyme Lipid 67 is a cholesterol derivatized with spermine to create a cationic lipid. GL67 has been proven to efficiently mediate gene transfer into mammalian cells and was a key formulation component that successfully completed clinical studies for the delivery of pDNA via inhalation. |
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| IUPAC Name | [(3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] N-(3-aminopropyl)-N-[4-(3-aminopropylamino)butyl]carbamate |
| Synonyms | N4-Cholesteryl-Spermine; Cholest-5-en-3-ol (3β)-, 3-[(3-aminopropyl)[4-[(3-aminopropyl)amino]butyl]carbamate]; Cholest-5-en-3-ol (3β)-, (3-aminopropyl)[4-[(3-aminopropyl)amino]butyl]carbamate; Cholesterol (3-aminopropyl)[4-[(3-aminopropyl)amino]butyl]carbamate; GL 67; N4-Spermine cholesteryl carbamate |
| Molecular Weight | 614.99 |
| Molecular Formula | C38H70N4O2 |
| Boiling Point | 690.9±55.0 °C at 760 mmHg |
| Density | 1.03±0.1 g/cm3 |
| Solubility | Soluble in DMSO |
| Appearance | White to off-white powder |
| Storage | Store at -20 °C |
| Canonical SMILES | CC(C)CCCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)OC(=O)N(CCCCNCCCN)CCCN)C)C |
| InChI | InChI=1S/C38H70N4O2/c1-28(2)11-8-12-29(3)33-15-16-34-32-14-13-30-27-31(17-19-37(30,4)35(32)18-20-38(33,34)5)44-36(43)42(26-10-22-40)25-7-6-23-41-24-9-21-39/h13,28-29,31-35,41H,6-12,14-27,39-40H2,1-5H3/t29-,31+,32+,33-,34+,35+,37+,38-/m1/s1 |
| InChI Key | KBBLYWGVXTZWCU-HMVYLTCSSA-N |
※ Please be kindly noted products are not for therapeutic use. We do not sell to patients.
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