CHAPS
| Catalog Number | BL-M001247 |
| CAS Number | 75621-03-3 |
| Description | CHAPS is a zwitterionic nondenaturing detergent for solubilizing membrane proteins. It is often used as a detergent in the solubilization and purification of membrane proteins for several advantageous reasons. It is also useful in ion exchange chromatography and isoelectric focusing as it is zwitterionic and does not exhibit a net charge between pH 2 to 12. |
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| IUPAC Name | 3-[dimethyl-[3-[[(4R)-4-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-trihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoyl]amino]propyl]azaniumyl]propane-1-sulfonate |
| Synonyms | N,N-Dimethyl-N-(3-sulfopropyl)-3-[[(3α,5β,7α,12α)-3,7,12-trihydroxy-24-oxocholan-24-yl]amino]-1-propanaminium Inner Salt; 3-[(3-Cholamidopropyl)dimethylammonio]-1-propanesulfonate |
| Molecular Weight | 614.88 |
| Molecular Formula | C32H58N2O7S |
| Melting Point | 156-158°C (dec.) |
| Flash Point | 320 °F |
| Purity | ≥98% |
| Density | 1.01 g/mL at 20°C |
| Solubility | Slightly soluble in Methanol, Water |
| Appearance | White to Off-white Solid |
| Application | Used as a non-denaturing biological detergent; CHAPS is a zwitterionic detergent used in the laboratory to solubilize biological macromolecules such as proteins. It is used as a non-denaturing solvent in the process of protein purification and is especially useful in purifying membrane proteins, which are often sparingly soluble or insoluble in aqueous solution due to their native hydrophobicity. |
| Shelf Life | 1 Year |
| Storage | -20°C under inert atmosphere |
| Percent Composition | C 62.51%, H 9.51%, N 4.56%, O 18.21%, S 5.21% |
| Canonical SMILES | CC(CCC(=O)NCCC[N+](C)(C)CCCS(=O)(=O)[O-])C1CCC2C1(C(CC3C2C(CC4C3(CCC(C4)O)C)O)O)C |
| InChI | InChI=1S/C32H58N2O7S/c1-21(8-11-29(38)33-14-6-15-34(4,5)16-7-17-42(39,40)41)24-9-10-25-30-26(20-28(37)32(24,25)3)31(2)13-12-23(35)18-22(31)19-27(30)36/h21-28,30,35-37H,6-20H2,1-5H3,(H-,33,38,39,40,41)/t21-,22+,23-,24-,25+,26+,27-,28+,30+,31+,32-/m1/s1 |
| InChI Key | UMCMPZBLKLEWAF-BCTGSCMUSA-N |
※ Please be kindly noted products are not for therapeutic use. We do not sell to patients.
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